Nutraceuticals and skin appearance: Is there any evidence to support the claims?

Posted 15 February 2018

“The rise of the nutraceutical market, specifically oral nutrition supplements claiming to improve skin appearance, is striking. This paper aims to examine the published scientific evidence for beneficial effects of nutraceuticals on skin appearance. An overview of skin physiology and intrinsic and extrinsic ageing is provided which underlies the potential physiological processes nutraceuticals purport to counter”.

“Current evidence for those without existing authorised claims (e.g. green tea extract, pomegranate extract, carotenoids, evening primrose oil, borage oil, fish oil, collagen and co-enzyme Q10) is reviewed, focussing primarily on evidence from randomised controlled trials where available, in relation to skin parameters including wrinkles and hydration”. 

“To date, the evidence for many ingredients in relation to skin appearance is limited, not sufficiently robust and/or inconsistent. Although there are a small number of human studies suggesting a potential benefit and some plausible biological mechanisms, much of the evidence Read the rest

Is Solal’s resveratrol dangering your health?

Posted 26 July 2013

Readers are aware that Solal’s central meme is “anti-aging” (The Anti-Aging Pill (R)), and the primary ingredient is resveratrol. The head pharmacist of Solal, Brent Murphy, argues that anti-aging effects of resveratrol in earthworms and flies can be extrapolated to humans. I have pointed out that there is insufficient evidence to suggest or even allow humans to ingest this ingredient, and in particular, warned that little is know about the safety of resveratrol especially ssince preliminary studies in animals point to a hormetic effect. (

A study published this week, concludes that “[I]n older men, a natural antioxidant compound found in red grapes and other plants – called resveratrol – blocks many of the cardiovascular benefits of exercise. This is the surprising result from a research project from the University of Copenhagen published today in The Journal of Physiology. The research unusually suggests that Read the rest

Is an “anti-aging pill” possible? Unlikely!

Posted 10 October 2011

Solal is selling an “anti-aging pill” containing among other, resveratrol. In a deconstru ction on this blog, the invalidity of the anti-aging claims was embarrassingly highlighted, showing that the research was conducted on, among other, worms, and extrapolated to humans. 

This did not appear to embarrass Solal for they continue to market this product – although with alteration of some of the claims (but still continue to claim “Research in animals on a high-calorie diet shows that resveratrol can increase lifespan and improve other factors associated with a longer life”).

Now here is where it becomes more interesting: resveratrol works through a “chemical” called sirtuin.

In a new development, it appears that sirtuin/resveratrol may not even be working in animal/insect models either:

“Claims that boosting levels of sirtuin enzymes can combat age-related diseases have suffered a blow. David Gems at University College London discovered Read the rest

Is an “anti-aging pill” possible?

Posted 18 April 2011

A principle in scientific research and science writing is to always go back to the primary source documents as far as possible. Ideally one would want to be able to double-check actual data from studies — but most of the time we have to be content with the published versions of the research. Here’s an example of how not going back to the original publication, and relying on a secondary source (a university newspaper) led to a mistake which has then been used in making false claims for a product.

Solal have been marketing an “anti-aging pill” which they claim/infer, among other, can slow down human ageing and extend the human lifespan.

Their website — which is no longer accessible since this blog was first published  (  showed the graphic above which asks “Is an anti-aging pill possible?” Text that implies this is factual … Read the rest