Tag Archives | Kava

Drug-related liver injury: call for better regulation of supplements

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Posted 26 July 2021

Medical Journal Australia – InSight 

DOCTORS at a Sydney liver transplant centre have raised concerns about the rising rate of drug-induced liver injury (DILI) cases linked to herbal and dietary supplements, warning these cases are often at the severest end of the spectrum.

Paracetamol remains the drug most commonly linked to DILI, a study of DILI cases at Royal Prince Alfred Hospital’s AW Morrow Gastroenterology and Liver Centre found.

There were 115 paracetamol-related cases and 69 non-paracetamol related cases at the centre over the 12 years to 2020. Of the non-paracetamol DILI cases, antibiotics and antifungals were the most commonly implicated medicines (19 cases). However, the proportion of cases linked with herbal and dietary supplements (15 cases) grew steadily over the period, from 15% to 47% of the non-paracetamol cases.

Cases linked with herbal or dietary supplements had especially poor prognoses, the study found, with 90-day … Read the rest

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Liver toxicity related to herbs and dietary supplements: Online table of case reports.

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Posted 07 November 2016

Over the past 50 years, approximately 19 herbs (minus germander and usnic acid that are no longer sold) and 13 dietary supplements (minus the six no longer sold and vitamin A & niacin due to excess) posed a possible risk for liver injures in certain individuals. The top three herbs with the most number of reported publications (but not cases studies) in descending order, were germander, black cohosh, kava extract, and green tea extract.

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