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Evidence lacking for “alternative” weight-loss therapies

Posted 07 July 2021

A systematic review of published research evaluating the efficacy of dietary supplements and “alternative therapies” for weight loss among people at least 18 years of age has found that supportive evidence is weak. Many clinical trials were also hampered by a significant risk of bias due to inconsistent testing methods. Problems with studies include small sample sizes, short follow-up periods, and poor study designs.
Reference: Batsis JA. A systematic review of dietary supplements and alternative therapies for weight loss. Obesity, June 23, 2021

Key findings included:

  • Out of 315 randomized controlled trials included in the review, 52 were classified as having a low risk of bias, of which 16 demonstrated significant weight changes for tested therapies compared to placebo.
  • No high-quality evidence supported acupuncture, calcium-vitamin D supplementation, chocolate/cocoa, phenylpropanolamineguar gumPhaseolus vulgarispyruvate, and mind-body interventions as weight-loss
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