Evidence for using bioidentical hormones found lacking

Posted 14 July 2020

An ad hoc committee convened by the National Academies of Sciences, Engineering, and Medicine has concluded that there is insufficient evidence to support the clinical utility of custom-compounded bioidentical hormone therapy (cBHT). Unlike the dozens of hormone therapy products that have been reviewed for safety and efficacy and are FDA-approved for treating symptoms resulting from natural, age-related hormone changes or other endocrine-based disorders, cBHT preparations are not required to be proven safe or effective before they are dispensed to patients. The NAS committee recommends: (a) restricting the use of cBHT preparations, (b) assessment of their difficulty to compound, and (c) additional education, oversight, and research. An estimated 26 to 33 million prescriptions for cBHT preparations cost upwards of $2 billion annually.

Reference: National Academies of Sciences, Engineering, and Medicine. Highlights: The clinical utility of compounded bioidentical hormone therapy (cBHT): A review of safety, effectiveness, and useRead the rest

Bioidentical Hormone Therapy: Myths Versus Facts

Posted 27 August 2018

Bioidentical hormones has remained controversial for many years.

For example, Solal a manufacturer of these products, claims on their website: “Saliva testing of steroid hormones, which is the truest reflection of your tissue levels of steroid hormones” [1] whereas the recent article (below) from the Medical Journal Australia states In fact, saliva tests are not considered a reliable method for establishing hormone levels”.


The article continues with: “Overall the scientific studies are positive regarding women with menopausal symptoms taking HRT. The same cannot be said for bioidentical hormones because they have not been widely or appropriately researched”.

Bioidentical Hormone Therapy: Myths Versus Facts

Medical Journal Australia MJA Issue 33 / 27 August 2018 

Read the rest

USA Endocrine Society hits compounded hormones and saliva testing

Posted 21 June 2016

The Endocrine Society has updated its statement on compounded “bioidentical hormones” and is urging clinicians not to prescribe them.

[Santoro N and others. Compounded bioidentical hormones in endocrinology practice: An Endocrine Society scientific statement. Journal of Endocrinology and Metabolism 101:1318-1343, 2016]

The document states:

“Much of the advertising associated with these custom-compounded preparations implies that naturally occurring hormones are superior to synthetic hormones and compounded formulations are better than FDA-approved formulations. In some instances, the purveyors . . . claim to produce combinations of hormones that mimic the circulating hormonal milieu of young adulthood and therefore prevent various ravages of aging. In the most extreme cases, advertisers imply that compounded natural hormones are risk-free when compared with conventional menopausal hormone therapy that uses bioidentical and/or synthetic hormones. . . . However, very few (if any) of these claims are supported by research, and in fact, Read the rest