Leanor – Dr Jacques Rossouw’s substantiation

The letter below is Dr Jacques Rossouw's substantiation for Leanor, i.e., his "proof" that the product works. 


RE:Leaner Herbal Slimming Concentrate

Thank you for the opportunity to comment on Leanor Herbal Slimming concentrate. This concentrate contains several actives. The literature support for each will be presented per active ingredient

Green tea (Camellia sinensis)

According to Dulloo and co-workers (Am J Clin Nutr 1999; 70:1040-1045) a green tea extract (50 mg caffeine and 90 mg epigallocatechin gallate) has thermogenic properties and promotes fat oxidation beyond that explained by its caffeine content per se. According to the authors green tea may play a role In the control of body composition via sympathetic activation of thermogenesis, fat oxidation, or both. Relative to placebo, treatment with the green tea extract resulted In a significant increase in 24-h energy expenditure (EE) (4%; P < 0.01) and a significant decrease in 24-h respiratory quotient (RQ) (from 0.88 to 0.85; P < 0.001) without any change in urinary nitrogen. Twenty-four-hour urinary norepinephrine excretion was higher during treatment with the green tea extract than with the placebo (40%. P < 0.05). Treatment with caffeine in amounts equivalent to those found in the green tea extract had no effect en EE and RQ nor on urinary nitrogen or catecholamines.

In a more recent study Chantre and Lairon in 2002 (Phytomedicine 9: 3-8) suggested that a green tree extract can be used as a natural product for the treatment of obesity exerting its activity by inhibition of lipases and stimulation of thermogenesis (after 3 months body weight was decreased by 4.6% and waist circumference by 4.48% using an 80% etnanolic dry extract standardized at 25% epigallocgtachin gallate (EGCG).

A similar finding was presented by Nagao and co-workers In 2005 (Am J Clin Nutr 2005; 81:122-129); they concluded that a daily consumption of tea containing 690 mg catechins for 12 weeks reduced body fat, suggesting that the ingestion of catechins might be useful in the prevention and improvement of lifestyte-related diseases, mainly obesity.

Another mode of action was proposed by Ashida et al. In 2004 (BioFacfors 2004; 22:

135-140). In their study on rats they concluded that green tea modulates the glucose uptake system in adipose tissue and skeletal muscle and suppresses the expression and/or activation of adipogenesis-related transcription factors.

The research conducted by Tsuchida and co-workers (Progress in Medicine, no 9. vol 22, September 2002) confirmed that the ingestion of catechins (588 mg/day for 12 weeks) reduced abdominal fat both in men and women.

Green tea, green tea extracts and EGCG have several health benefits as reviewed in an article by the Vitamin Information Centre (Medical Update, no 42, October 2004). In . terms of obesity it was however concluded that better designed studies are needed to determine the size of acute and long-term thermogenic or anti-obesity effects of green tea.

In conclusion: the potential for green tea to influence body weight should be investigated more thoroughly as initial results appear positive.

Garcinia cambogia (Gambodia)

(-)-Hydroxycitrate (HCA) Is an ingredient extracted from the rind of the fruit Garcinia cambogia and is promoted as a weight loss agent (Inhibits ATP-citrate lyase). Results on the effects of HCA on appetite and body weight relation showed positive and negative outcomes (as cited by Westerterp-Plantenga and Kovacs, 2002). Westerterp-Plantenga and Kovacs (International Journal of Obesity 2002. 870-872) showed in their study on 24 overweight subjects that the daily administration of 900 mg/day HCA for two weeks reduced energy intake white satiety was sustained. They however concluded that HCA might not primarily be a weight loss agent, as indicated by the minor changes observed in body weight, but might be effective in preventing weight (re)gain in humans.

A limitation of the above study was that it was conducted for two weeks – more pronounced affects could possibly be detected after longer periods of supplementation viz, three months,

Other Ingredients

The Herbal Medicine, Expanded Commission E Monographs (2000) and Natural Medicines Comprehensive Database; Monographs, acceptable reference material on herbs, were consulted to validate the inclusion of the remaining ingredients. Lemon Is included as a natural flavouring agent and is a source of vit C. Dandelion is used as a diuretic, has effects on digestion and bile flow, and could thus be of assistance with dyspepsia, flatulence and constipation. Goldenrod has antioxidant propertes among others and is classified as an aquaretic. Ginger aids the digestive process by promoting the secretion of saliva and gastric juices. Globe artichoke Is of benefit for symptoms such as nausea, bloating, abdominal pain and flatulance (choleretic and diuretic). Panax ginseng extract has according to Kim and Park (Pharmacological Research 2003, 48: 511-513) hypolipidemic effects over and above its ability to enhance mental and physical capacities.


Although a clinical trial has not beep conducted on the effects of the Leanor Herbal Slimming Concentrate on weight loss, I am of the opinion that the individual ingredients will instill such activity. The synergistic effect of the individual ingredients makes this supplement useful in assisting people with weight loss while detoxifying, reducing water retention and improving digestive functions.

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