Is Solal’s resveratrol dangering your health?

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Posted 26 July 2013

Readers are aware that Solal’s central meme is “anti-aging” (The Anti-Aging Pill (R)), and the primary ingredient is resveratrol. The head pharmacist of Solal, Brent Murphy, argues that anti-aging effects of resveratrol in earthworms and flies can be extrapolated to humans. I have pointed out that there is insufficient evidence to suggest or even allow humans to ingest this ingredient, and in particular, warned that little is know about the safety of resveratrol especially ssince preliminary studies in animals point to a hormetic effect. (http://www.camcheck.co.za/anti-aging-pill/

A study published this week, concludes that “[I]n older men, a natural antioxidant compound found in red grapes and other plants – called resveratrol – blocks many of the cardiovascular benefits of exercise. This is the surprising result from a research project from the University of Copenhagen published today in The Journal of Physiology. The research unusually suggests that eating a diet rich in antioxidants may actually counteract many of the health benefits of exercise, including reduced blood pressure and cholesterol.” (Resveratrol has been found in rats to boost exercise performance by improving strength and endurance)

This is a clear warning, if you are taking a resveratrol prouct, you may be placing your health at risk. So can individuals taking Solal’s Anti-Aging pill sue Solal for the negative effects now documented that they personally experience?

Antioxidants – too much of a good thing?

http://news.ku.dk/all_news/2013/2013.7/antioxidants_too_much_of_a_good_thing/

 

Antioxidants In older men, a natural antioxidant compound found in red grapes and other plants – called resveratrol – blocks many of the cardiovascular benefits of exercise. This is the surprising result from a research project from the University of Copenhagen published today in The Journal of Physiology. 

The research unusually suggests that eating a diet rich in antioxidants may actually counteract many of the health benefits of exercise, including reduced blood pressure and cholesterol. 

Resveratrol has received widespread attention as a possible anti-aging compound and is now widely available as a dietary supplement; much has been made of its role in explaining the cardiovascular health benefits of red wine, and other foods. 

In contrast to earlier studies in animals in which resveratrol improved the cardiovascular benefits of exercise, this study in humans has provided surprising and strong evidence that in older men, resveratrol has the opposite effect.

New view on antioxidants 

What is emerging is a new view that antioxidants are not the fix for everything, and that some degree of oxidant stress may be necessary for the body to work correctly. This pivotal study suggests that reactive oxygen species, generally thought of as causing aging and disease, may be a necessary signal that causes healthy adaptations in response to stresses like exercise. So too much of a good thing (like antioxidants in the diet) may actually be detrimental to our health. 

“We studied 27 healthy, physically inactive men around 65 years old for 8 weeks. During the 8 weeks all of the men performed high-intensity exercise training and half of the group received 250 mg of resveratrol daily, whereas the other group received a placebo pill (a pill containing no active ingredient). The study design was double-blinded, thus neither the subjects nor the investigators knew which participant that received either resveratrol or placebo”, says Ph.D. student Lasse Gliemann, University of Copenhagen, who was one of the researchers in the study. 

He continues: “We found that exercise training was highly effective in improving cardiovascular health parameters, but resveratrol supplementation attenuated the positive effects of training on several parameters including blood pressure, plasma lipid concentrations and maximal oxygen uptake.” 

 “We were surprised to find that resveratrol supplementation in aged men blunts the positive effects of exercise training on cardiovascular health parameters, in part because our results contradict findings in animal studies”, adds professor Ylva Hellsten, the leader of the project, and she continues: “It should be noted that the quantities of resveratrol given in our research study are much higher than what could be obtained by intake of natural foods. 

This research adds to the growing body of evidence questioning the positive effects of antioxidant supplementation in humans.

Contact 

Ph.d student Lasse Gliemann Jensen
Department of Nutrition, Exercise and Sports
Phone: +45 35 32 16 08

Professor Ylva Hellsten
Department of Nutrition, Exercise and Sports
Phone: +45 35 32 16 16

 

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Resveratrol Blunts the Positive Effects of Exercise Training on Cardiovascular Health in Aged Men

Lasse Gliemann1,4, Jakob Friis Schmidt1, Jesper Olesen2, Rasmus Sjørup Biensø2, Sebastian Louis Peronard1, Simon Udsen Grandjean1, Stefan Peter Mortensen3, Michael Nyberg1, Jens Bangsbo1, Henriette Pilegaard2 and Ylva Hellsten1

Author Affiliations

  1. Nutrition, Exercise and Sports, Denmark;
  2. Centre of Inflammation and Metabolism, Denmark;
  3. Rigshospitalet, Denmark

* Corresponding author; email: [email protected] 

http://jp.physoc.org/content/early/2013/07/19/jphysiol.2013.258061.abstract 

Abstract 

Aging is thought to be associated with decreased vascular function partly due to oxidative stress. Resveratrol is a polyphenol, which, in animal studies has been shown to decrease atherosclerosis, improve cardiovascular health and physical capacity, in part through its effects on Sirtuin 1 signaling and through an improved antioxidant capacity. We tested the hypothesis that resveratrol supplementation enhances training-induced improvements in cardiovascular health parameters in aged men. Twenty-seven healthy physically inactive aged men (age: 65 ± 1 years; BMI: 25.4 ± 0.7 kg/m2; MAP: 95.8 ± 2.2 mmHg; maximal oxygen uptake: 2488 ± 72 ml O2 min-1) were randomized into 8 weeks of either daily intake of either 250 mg trans resveratrol (n = 14) or of placebo (n = 13) concomitant with high-intensity exercise training. Exercise training lead to a 45% greater (P < 0.05) increase in maximal oxygen uptake in the placebo group than in the resveratrol group and to a decrease in MAP in the placebo group only (-4.8 ± 1.7 mmHg; P < 0.05). The interstitial level of vasodilator prostacyclin was lower in the resveratrol than in the placebo group after training (980 ± 90 versus 1174 ± 121 pg ml-1; P < 0.02) and muscle TBX synthase was higher in the resveratrol group after training (P < 0.05). Resveratrol administration also abolished the positive effects of exercise on LDL, TC/HDL ratio and triglycerides concentrations in blood (P < 0.05). Resveratrol did not potentiate the effect of exercise training on atherosclerosis marker VCAM-1. Sirtuin 1 protein levels were not affected by resveratrol supplementation. These findings indicate that, whereas exercise training effectively improves several cardiovascular health parameters in aged men, concomitant resveratrol supplementation blunts most of these effects.

 

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11 Responses to Is Solal’s resveratrol dangering your health?

  1. melisentia 2 June, 2015 at 10:12 am #

    I will continue buying Solal products. The quality of all their products are outstanding. I’m exceptionally impressed. A very happy consumer.

    • Harris 2 June, 2015 at 5:20 pm #

      @Melisentia
      Do you know from testing their products in a laboratory that their products are outstanding or is this your opinion and belief?

  2. Mario 11 September, 2015 at 8:06 am #

    I think this actually proves even more that resveratrol has a effect on humans too. Not everybody is surprised by this finding. t depends very much from which angel you are looking at the issue. (Hard) exercise is nothing else then stressing the body fisically. The body tries to adapt at this stress at the expense of long term “wear & tear”. Yes, a well exercised person may have a more fit body but it won’t neccesarely live longer! Actually the opposite seems to be the case. Resveratrol tries to dampen the “wear and tear” the body experiences during exercise. Therefore the body does not need to adapt as much. Did you new that the best way to prolong life is by reducing metabolisme? That is just the oposite of exercise! Life time prisoners usually outlive their piers. Why?

  3. Odilo von Steinitz 9 January, 2016 at 2:13 pm #

    Most modern papers in the medical field are just there to prove a point. The experiments are slanted to come up with the desired results.

    ERGO: I know 8 men in my family and outside who died in their mid eighties. They all had close to genius IQs.
    They also, for most of their lives consumed at least 700ml of hard liquor per day. Must we therfore assume that to maintain good health and a high mental capacity into our eighties we must have a bottle of Vodka per day.
    I am sure one could make a superficial case for that in a scientific experiment by choosing the right subjects.

    • Harris 11 January, 2016 at 8:25 am #

      @Odilo
      Sadly your example is illogical. This is not how research works.

  4. Odilo von Steinitz 18 January, 2016 at 5:19 pm #

    @Harris

    That was my point! I rest my case….

    • Harris 18 January, 2016 at 7:20 pm #

      @Odilo
      You totally missed what I was saying – I was saying that your example was an illogical example because it is not a valid example of how research is conducted or works – it shows your lack of appreciation of how research works! If you are going to make a valid point, then your example must be valid and logical. Yours was not.

  5. Odilo von Steinitz 25 January, 2016 at 7:14 am #

    @Harris

    Talking about being “illogical you may want to look in the mirror. YOU TOTALLY MISSED MY SARCASM!

    The point I made (OPINIOUN, IF YOU WILL) -please try and understand – is my conviction that the alleged research papers about Resveratrol was NOT based on solid research
    at all but were just sly and targeted propaganda pieces dressed up as solid research.

    And that’s where you are right: Propaganda are is not scientific research.

    On a larger scale my considered OPINION (NOT research) is that ANY papers issued, promoted and/or financed, either openly or clandestinely by the Pharmaceutical industry are most likely NOT products of genuine research according to the prescribed scientific method, but pieces of targeted propaganda.

    • Harris 25 January, 2016 at 7:55 am #

      @Odilo
      Many of the papers issued are influenced by the pharmaceutical industry: but not all are. One cannot tar EVERY study sponsored by Big Pharma as biased (although many are) – one has to assesses each individually.

      There have been no human-studied favourable resveratrol studies. I had contact with one of the researchers whose work was being abused by the CAM industry (no different to Big Pharma), who was threatened with legal suits if he countered their propoganda and abuse of his conclusions. CAM have come to act no different to Big Pharma. When money is to be made, they both act the same.

  6. Odilo von Steinitz 25 January, 2016 at 7:16 am #

    @Harris

    I also suspect that your motives are dodgy – from the threads I have read.

    • Harris 25 January, 2016 at 7:56 am #

      @Odilo
      And what may these be?

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