Posted 26 July 2013
Readers are aware that Solal’s central meme is “anti-aging” (The Anti-Aging Pill (R)), and the primary ingredient is resveratrol. The head pharmacist of Solal, Brent Murphy, argues that anti-aging effects of resveratrol in earthworms and flies can be extrapolated to humans. I have pointed out that there is insufficient evidence to suggest or even allow humans to ingest this ingredient, and in particular, warned that little is know about the safety of resveratrol especially ssince preliminary studies in animals point to a hormetic effect. (http://www.camcheck.co.za/anti-aging-pill/)
A study published this week, concludes that “[I]n older men, a natural antioxidant compound found in red grapes and other plants – called resveratrol – blocks many of the cardiovascular benefits of exercise. This is the surprising result from a research project from the University of Copenhagen published today in The Journal of Physiology. The research unusually suggests that eating a diet rich in antioxidants may actually counteract many of the health benefits of exercise, including reduced blood pressure and cholesterol.” (Resveratrol has been found in rats to boost exercise performance by improving strength and endurance)
This is a clear warning, if you are taking a resveratrol prouct, you may be placing your health at risk. So can individuals taking Solal’s Anti-Aging pill sue Solal for the negative effects now documented that they personally experience?
Antioxidants – too much of a good thing?
Antioxidants In older men, a natural antioxidant compound found in red grapes and other plants – called resveratrol – blocks many of the cardiovascular benefits of exercise. This is the surprising result from a research project from the University of Copenhagen published today in The Journal of Physiology.
The research unusually suggests that eating a diet rich in antioxidants may actually counteract many of the health benefits of exercise, including reduced blood pressure and cholesterol.
Resveratrol has received widespread attention as a possible anti-aging compound and is now widely available as a dietary supplement; much has been made of its role in explaining the cardiovascular health benefits of red wine, and other foods.
In contrast to earlier studies in animals in which resveratrol improved the cardiovascular benefits of exercise, this study in humans has provided surprising and strong evidence that in older men, resveratrol has the opposite effect.
New view on antioxidants
What is emerging is a new view that antioxidants are not the fix for everything, and that some degree of oxidant stress may be necessary for the body to work correctly. This pivotal study suggests that reactive oxygen species, generally thought of as causing aging and disease, may be a necessary signal that causes healthy adaptations in response to stresses like exercise. So too much of a good thing (like antioxidants in the diet) may actually be detrimental to our health.
“We studied 27 healthy, physically inactive men around 65 years old for 8 weeks. During the 8 weeks all of the men performed high-intensity exercise training and half of the group received 250 mg of resveratrol daily, whereas the other group received a placebo pill (a pill containing no active ingredient). The study design was double-blinded, thus neither the subjects nor the investigators knew which participant that received either resveratrol or placebo”, says Ph.D. student Lasse Gliemann, University of Copenhagen, who was one of the researchers in the study.
He continues: “We found that exercise training was highly effective in improving cardiovascular health parameters, but resveratrol supplementation attenuated the positive effects of training on several parameters including blood pressure, plasma lipid concentrations and maximal oxygen uptake.”
“We were surprised to find that resveratrol supplementation in aged men blunts the positive effects of exercise training on cardiovascular health parameters, in part because our results contradict findings in animal studies”, adds professor Ylva Hellsten, the leader of the project, and she continues: “It should be noted that the quantities of resveratrol given in our research study are much higher than what could be obtained by intake of natural foods.
This research adds to the growing body of evidence questioning the positive effects of antioxidant supplementation in humans.
Ph.d student Lasse Gliemann Jensen
Department of Nutrition, Exercise and Sports
Phone: +45 35 32 16 08
Professor Ylva Hellsten
Department of Nutrition, Exercise and Sports
Phone: +45 35 32 16 16
Resveratrol Blunts the Positive Effects of Exercise Training on Cardiovascular Health in Aged Men
Lasse Gliemann1,4, Jakob Friis Schmidt1, Jesper Olesen2, Rasmus Sjørup Biensø2, Sebastian Louis Peronard1, Simon Udsen Grandjean1, Stefan Peter Mortensen3, Michael Nyberg1, Jens Bangsbo1, Henriette Pilegaard2 and Ylva Hellsten1
- Nutrition, Exercise and Sports, Denmark;
- Centre of Inflammation and Metabolism, Denmark;
- Rigshospitalet, Denmark
* Corresponding author; email: firstname.lastname@example.org
Aging is thought to be associated with decreased vascular function partly due to oxidative stress. Resveratrol is a polyphenol, which, in animal studies has been shown to decrease atherosclerosis, improve cardiovascular health and physical capacity, in part through its effects on Sirtuin 1 signaling and through an improved antioxidant capacity. We tested the hypothesis that resveratrol supplementation enhances training-induced improvements in cardiovascular health parameters in aged men. Twenty-seven healthy physically inactive aged men (age: 65 ± 1 years; BMI: 25.4 ± 0.7 kg/m2; MAP: 95.8 ± 2.2 mmHg; maximal oxygen uptake: 2488 ± 72 ml O2 min-1) were randomized into 8 weeks of either daily intake of either 250 mg trans resveratrol (n = 14) or of placebo (n = 13) concomitant with high-intensity exercise training. Exercise training lead to a 45% greater (P < 0.05) increase in maximal oxygen uptake in the placebo group than in the resveratrol group and to a decrease in MAP in the placebo group only (-4.8 ± 1.7 mmHg; P < 0.05). The interstitial level of vasodilator prostacyclin was lower in the resveratrol than in the placebo group after training (980 ± 90 versus 1174 ± 121 pg ml-1; P < 0.02) and muscle TBX synthase was higher in the resveratrol group after training (P < 0.05). Resveratrol administration also abolished the positive effects of exercise on LDL, TC/HDL ratio and triglycerides concentrations in blood (P < 0.05). Resveratrol did not potentiate the effect of exercise training on atherosclerosis marker VCAM-1. Sirtuin 1 protein levels were not affected by resveratrol supplementation. These findings indicate that, whereas exercise training effectively improves several cardiovascular health parameters in aged men, concomitant resveratrol supplementation blunts most of these effects.