Posted 27 June 2018
A meta-analysis of 10 randomized controlled trials involving 77,917 individuals found no evidence that a mean of 4.4 years of supplementation with marine-derived omega-3 fatty acids was effective in preventing fatal or nonfatal coronary heart disease, strokes, or the need for procedures to restore circulation. The supplementation was also ineffective in preventing these cardiovascular outcomes in subgroups of individuals at elevated risk.
Reference: Aung T. Associations of omega-3 fatty acid supplement use with cardiovascular disease risks. JAMA Cardiology 3:225-234, 2018
The findings do not support the conclusion of a 2017 science advisory from the American Heart Association which suggested that fish oil supplementation is reasonable treatment for people with coronary heart disease but was based on only one trial of patients with heart failure. Both the 2017 science advisory and the new meta-analysis agreed that there is no evidence of benefit from fish oil supplementation for patients at high-risk of heart disease who have had no clinical symptoms. Four more large randomized controlled trials of fish oil supplementation are currently underway.
Reference: Abbasi J. Another nail in the coffin for fish oil supplements. JAMA 319:1851-1852, 2018
Source: Consumer Health Digest #18-25 June 24 2018