Archive | Supplements

Drug-related liver injury: call for better regulation of supplements

Continue Reading 0

Posted 26 July 2021

Medical Journal Australia – InSight 

DOCTORS at a Sydney liver transplant centre have raised concerns about the rising rate of drug-induced liver injury (DILI) cases linked to herbal and dietary supplements, warning these cases are often at the severest end of the spectrum.

Paracetamol remains the drug most commonly linked to DILI, a study of DILI cases at Royal Prince Alfred Hospital’s AW Morrow Gastroenterology and Liver Centre found.

There were 115 paracetamol-related cases and 69 non-paracetamol related cases at the centre over the 12 years to 2020. Of the non-paracetamol DILI cases, antibiotics and antifungals were the most commonly implicated medicines (19 cases). However, the proportion of cases linked with herbal and dietary supplements (15 cases) grew steadily over the period, from 15% to 47% of the non-paracetamol cases.

Cases linked with herbal or dietary supplements had especially poor prognoses, the study found, with 90-day … Read the rest

Continue Reading 0

Evidence does not support vitamin supplementation for heart health

Continue Reading 0

Posted 11 June 2021

Researchers who searched PubMed for the phrase “vitamin supplements and cardiovascular health” have found no significant evidence that supplementation with vitamins A, B6, B12, C, D, E, or K, folic acid, or multivitamins improved cardiovascular functioning or decreased the incidence of heart attacks or strokes in the general public. Their review, based on 87 studies that met their inclusion criteria, concluded:

A recommendation to suggest vitamin use to maintain and/or improve clinical cardiovascular outcomes cannot not be made for the general public. Instead, counseling people to follow a healthy diet, rich in fruits and vegetables seems more appropriate to improve and maintain cardiovascular health.

Reference: Simsek B. and others. Effects of vitamin supplements on clinical cardiovascular outcomes: Time to move on!—A comprehensive review. Clinical Nutrition ESPEN 42:1-14, April 2021

Source: Consumer Health Digest #21-22 June 6,, 2021

Read the rest
Continue Reading 0

Zinzino: 17 unsettling things you need to consider

Continue Reading 0

Posted 10 December 2020

I have been asked by a number of readers about Zinzino. 

Zinzino is a MLM (Multilevel marketing) company, very similar to Herbalife, Amway etc. 

Multilevel marketing (MLM) is a strategy that some direct sales companies use to encourage existing distributors to recruit new distributors. In MLM schemes, there can be hundreds or thousands of members worldwide, but relatively few earn meaningful incomes from their efforts, indicating a possible pyramid scheme. Investopedia

There is no robust evidence to confirm that these products have any significant clinically proven benefits over other vitamin supplements.

A number of relevant questions and answers regarding this company, and its products, can be found at this site which asks:

Curing the world of all its ailments, lengthening the human lifespan, and hitting a million customers in the next few years are just a few of their ambitions. But can Read the rest

Continue Reading 0

Collagen hype scrutinised

Continue Reading 0

Posted 19 November 2020

Consumer Reports has spotlighted the lack of scientific support for claims that consuming collagen powders, pills, and foods can result in smoother skin, shinier hair, stronger nails, healthier joints, and more lean muscle mass.
Reference: Wadyka S. The real deal on collagen. Consumer Reports, Oct 13, 2020

The article notes that Nutrition Business Journal projects collagen supplement sales in the U.S. to reach $298 million this year—up from $73 million in 2015. Collagen is a protein that holds skin, tendons, ligaments, bones, and cartilage together. But that doesn’t mean that consumers benefit from collagen in supplements or added to foods, such as energy bars, oatmeal, smoothies, coffee creamers, and popcorn. The human body makes collagen from glycine, proline, hydroxyproline, and other amino acids when proteins (not limited to collagen) are digested. The bottom line in the article is that “until there’s more conclusive evidence in Read the rest

Continue Reading 0

Does high-dose Omega-3 Fatty Acids protect against adverse cardiovascular events?

Continue Reading 0

Posted 16 November 2020

Conclusion:
Among statin-treated patients at high cardiovascular risk, the addition of omega-3 CA, compared with corn oil, to usual background therapies resulted in no significant difference in a composite outcome of major adverse cardiovascular events. These findings do not support use of this omega-3 fatty acid formulation to reduce major adverse cardiovascular events in high-risk patients.

Effect of High-Dose Omega-3 Fatty Acids vs Corn Oil on Major Adverse Cardiovascular Events in Patients at High Cardiovascular Risk – The STRENGTH Randomized Clinical Trial

JAMA. Published online November 15, 2020. doi:10.1001/jama.2020.22258

Key Points

Question  In statin-treated patients with high cardiovascular risk, high triglycerides, and low HDL cholesterol levels, does adding a carboxylic acid formulation of omega-3 fatty acids (eicosapentaenoic acid and docosahexaenoic acid) to background therapy improve cardiovascular outcomes?

Findings  In this randomized clinical trial of 13 078 patients that was stopped early, daily supplementation with omega-3 Read the rest

Continue Reading 0

No evidence that vitamin D prevents coronavirus, say experts

Continue Reading 0

Posted 30 June 2020

Nice says topic is under review, but still advises taking supplements for bone health

Haroon Siddique Published on Mon 29 Jun 2020 18.12 BST

The Guardian

No evidence exists to support taking vitamin D supplements to prevent Covid-19, UK public health experts have found.

A rapid review of evidence for claims that the so-called sunshine vitamin could reduce the risk of coronavirus was launched amid concerns about the disproportionate number of black, Asian and minority ethnic people contracting and dying from the disease. Higher levels of melanin in the skin lead to less absorption of vitamin D from sunlight.

However, on Monday, the National Institute for Health and Care Excellence (Nice) said that, having examined five studies, it had not found evidence to support any benefit from vitamin D with respect to Covid-19.

“While there are health benefits associated with vitamin D, our rapid evidence summary Read the rest

Continue Reading 0

Covid-19: Can ‘boosting’ your immune system protect you?

Continue Reading 0

Posted 11 April 2020

Forget kombucha and trendy vitamin supplements – they are nothing more than magic potions for the modern age.

“Spanish Influenza – what it is and how it should be treated,” read the reassuringly factual headline to an advert for Vick’s VapoRub back in 1918. The text beneath included nuggets of wisdom such as “stay quiet” and “take a laxative”. Oh, and to apply their ointment liberally, of course.

The 1918 flu pandemic was the most lethal in recorded history, infecting up to 500 million people (a quarter of the world’s population at the time) and killing tens of millions worldwide.

But with crisis comes opportunity, and the – sometimes literal – snake oil salesmen were out in force. Vick’s VapoRub had stiff competition from a panoply of crackpot remedies, including Miller’s Antiseptic Snake Oil, Dr

Read the rest
Continue Reading 0

Dangers of dietary supplements spotlighted

Continue Reading 0

Posted 19 February 2020

Michael White, a professor of pharmacy at the University of Connecticut, has summarized how consumers are endangered by the U.S. dietary supplement marketplace. The problems include (a) microbial contamination, (b) heavy metal contamination, (c) prescription drug adulteration, (d) herb substitutions, (e) added ingredients to herbal products, and (f) inaccurate labeling of ingredient dosages. He blames the Dietary Supplement Health and Education Act (DSHEA) of 1994, which allows supplement and herbal products to be marketed without providing proof of their quality to the Food and Drug Administration. Reference: White CM. Dietary supplements pose real dangers to patients. Annals of Pharmacotherapy. Jan 24, 2020

Calling the situation a “Wild West scenario,” White concludes:

The DSHEA Act was written to limit the FDA’s oversight of dietary products, and it has done just that. Health professional and consumer advocacy organizations need to come together and with one voice sound Read the rest

Continue Reading 0