Cannabidiol Products Are Everywhere, but Should People Be Using Them?

November 20, 2019

Rita Rubin, MA

JAMA. 2019;322(22):2156-2158. doi:10.1001/jama.2019.17361

General internist Brent Bauer, MD, sees patients at the Mayo Clinic in Rochester, Minnesota, one of the most esteemed medical centers in the world.

And yet, some of his patients have sought relief from a variety of ills with ubiquitous, unregulated products they can pick up at 7/Eleven or order online (although not from Amazon, whose selling guidelines prohibit them).

The products’ labels say they contain cannabidiol, or CBD, 1 of more than 100 identified compounds in the cannabis plant, commonly known as marijuana. Unlike tetrahydrocannabinol (THC), the other well-known cannabinoid in cannabis, CBD doesn’t make users high. Bauer’s patients take CBD products to reduce pain, sleep better, and ease anxiety.

“Right now we have [CBD] popping up everywhere,” said Bauer, director of research for Mayo’s Integrative Medicine program. “I’ve heard it described as the Wild West meets Wall Street. Read the rest

Science Has Shown These Five Weight Loss Supplements Are a Waste of Money

Posted 11 December 2019

By Clare Collins, Lee Ashton & Rebecca Williams

The Conversation 8 Dec 2019

When you google “weight loss” the challenge to sort fact from fiction begins.

These five supplements claim to speed up weight loss, but let’s see what the evidence says.

1. Raspberry ketones

Raspberry ketones, sold as weight loss tablets, are chemicals found in red raspberries responsible for that distinct raspberry flavour and smell. You can also make raspberry ketones in a lab.

A study in obese rats found raspberry ketones reduced their total body fat content.

In one study, 70 adults with obesity were put on a weight loss diet and exercise program, and randomised to take a supplement containing either raspberry ketones, or other supplements such as caffeine or garlic, or a placebo.

Only 45 participants completed the study. The 27 who took a supplement lost about 1.9 kilos, compared Read the rest

Prohibited drug found in dietary supplements

Posted 11 December 2019

Piracetam has been touted as a brain-enhancing substance despite poor evidence of its efficacy. Although it is not approved as a drug and is prohibited as a dietary supplement ingredient in the United States, U. S.-based researchers were able to purchase two samples of each of 12 brands of piracetam products online from sellers they identified through a Google search.

Reference: Cohen P and others. Presence of piracetam in cognitive enhancement dietary supplements. JAMA Internal Medicine. doi:https://doi.org/10.1001/jamainternmed.2019.5507, Nov 25, 2019

Five of those brands were labeled as dietary supplements. Chemical analysis revealed that the piracetam content ranged from 85% to 188% of the labeled dosage. The researchers noted that (a) known adverse effects of piracetam include anxiety, insomnia, agitation, depression, drowsiness, and weight gain, and (b) the effects of the doses found, particularly in elderly consumers with poor kidney function are unknown. They Read the rest

Complications attributed to intravenous colloidal silver

Posted 11 December 2019

A report has been published about three people whose condition worsened after receiving multiple intravenous infusiions at a “wellness center” for alleged Lyme disease. Each was eventually seen by a hematologist and found to have copper-deficiency-induced anemia with abnormal blood cell counts. One patient was then treated successfully with supplemental copper apheresis and an antidepressant. The other two patients refused apheresis and follow-up with the hematologist. After the authors of this case series complained to the Texas Medical Board, the initial treating physician agreed to voluntarily surrender his medical license.

Reference: Natelson EA and others. Anemia and leukopenia following intravenous colloidal silver infusions—clinical and hematological features, unique peripheral blood film appearance and effective therapy with supplemental oral copper and apheresis. Clinical Case Reports 7:157-1762, 2019

The authors concluded:

As this report illustrates, the use of infused colloidal silver as a primary or adjunctive therapy Read the rest